祝贺黄丽霏在Journal of Materials Chemistry B综述接受发表！

祝贺黄丽霏名为《Multicomponent Carrier-free Nanodrugs for Cancer Treatment》的综述在Journal of Materials Chemistry B接受发表！中风后的中枢神经系统（CNS）功能恢复仍然是一个主要挑战，因为神经再生很难实现。在本研究中，用骨髓间充质干细胞（BMSC）负载由电纺支架的纳米纤维和自适应和可注射水凝胶组成的刚柔复合支架，并研究了这些负载的BMSC对缺血性损伤的影响。对骨髓间充质干细胞的活力、迁移、轴突生长、血管生成能力和旁分泌作用的体外分析表明，复合支架中负载的骨髓基质干细胞比盐水中的骨髓基质细胞具有更好的治疗效果。总之，负载在新型复合支架中的骨髓基质干细胞具有明显的神经保护作用，通过增强缺血性中风后大脑中的血管生成和神经再生来减轻缺血性损伤，这些结果为通过细胞移植在临床上治疗中枢神经系统疾病提供了一种有前途的方法。

摘要：Central nervous system (CNS) function recovery following stroke remains a major challenge because neural regeneration is difficult to achieve. In this study, rigid-flexible composite scaffolds consisting of nanofibers from electrospun scaffolds and self-adapting and injectable hydrogel were loaded with bone marrow mesenchymal stem cells (BMSCs), and the effects of these loaded BMSCs on ischemic insult were investigated. In vitro analysis of the viability, migration, neurite growth, angiogenic capacity, and paracrine effects of BMSCs indicated that BMSCs loaded in composite scaffolds had a better therapeutic effect than those BMSCs in saline. Furthermore, in vivo, BMSCs loaded in composite scaffolds significantly reduced the extent of brain edema and the infarct volume, alleviated neurological deficits, markedly attenuated microglial and astrocyte overactivation, and increased neuronal proliferation and vascular growth. Bioinformatics analysis revealed that BMSCs loaded in composite scaffolds could decrease the level of exosomal miR-206e3p and consequently increase the activity of the PI3K/AKT signaling pathway. In conclusion, BMSCs loaded in novel composite scaffolds exert obvious neuroprotective effects, attenuating ischemic injury by enhancing angiogenesis and neural regeneration in the brain after ischemic stroke, and these results provide a promising approach for treating CNS diseases in the clinic via cell transplantation.