祝贺杜芳林的文章在Carbohydrate Polymers接受发表!
杜芳林在Carbohydrate Polymers发表题为《Hydrophilicchitosan/graphene oxidecomposite sponge for rapidhemostasis and non-rebleeding removal》的文章。本文报道了一种机械强度稳定、吸液速度快、内外凝血刺激能力强的亲水性壳聚糖/氧化石墨烯复合海绵(CSAG)的设计。一方面,CSAG表现出卓越的止血性能,在两个体内严重出血模型中,其止血效果明显优于两种商用止血剂。另一方面,CSAG具有较低的组织粘附性,其剥离力比商品纱布低约79.3%。
摘要:Hydrophilic hemostatic sponge plays an important role in trauma bleeding control because of its robust coag-ulant functions. However, its strong tissue adhesion can easily result in wound tear and rebleeding during removing the sponge. Herein, the design of a hydrophilic anti-adhesive chitosan/graphene oxide composite sponge (CSAG) that possesses stable mechanical strength, rapid liquid absorption and strong intrinsic/extrinsic coagulation stimulations, is reported. For one thing, CSAG exhibits outstanding hemostatic performance, which significantly outperforms two commercial hemostats in two in vivo serious bleeding models. For another, CSAG shows low tissue adhesion; its peeling force is approximately 79.3 % lower than the commercial gauze. More-over, in the peeling process, CSAG triggers partial detachment of the blood scab, because of the exist of bubbles or cavities at the interface, allowing the CSAG to be easily and safely peeled off from the wound without rebleeding. This study opens new avenues in constructing anti-adhesive trauma hemostatic materials.