祝贺卜凡强的文章在Bioactive Materials接受发表！

卜凡强在Bioactive Materials发表题为《Enhancing near-infrared II photodynamic therapy with nitric oxide for eradicating multidrug-resistant biofilms in deep tissues》的文章。本研究设计了由聚合物PNIR-II和聚合物PSNO组装而成的可降解NPs。其中，PNIR-II由于聚合物链中对GSH敏感的二硫结构，进入GSH过表达的生物膜微环境后会迅速降解。同时，GSH还能触发PSNO释放NO, PSNO由于其对氧化敏感的硫酮结构，在暴露于ROS时被降解。PNIR-II可被NIR-II光激发;即使激发光穿过2.6 cm的组织屏障，PNIR-II也能保持50%的PDT效率，为深部组织生物膜的破坏提供了新的前景。

摘要：Nitric oxide (NO) enhanced photodynamic therapy (PDT) is a promising approach to overcome drug tolerance and resistance to biofilm but is limited by its short excitation wavelengths and low yield of reactive oxygen species (ROS). Herein, we develop a compelling degradable polymer-based near-infrared II (NIR-II, 1000–1700 nm) photosensitizer (PNIR-II), which can maintain 50 % PDT efficacy even under a 2.6 cm tissue barrier.
Remarkably, PNIR-II is synthesized by alternately connecting the electron donor thiophene to the electron acceptors diketopyrrolopyrrole (DPP) and boron dipyrromethene (BODIPY), where the intramolecular charge transfer properties can be tuned to increase the intersystem crossover rate and decrease the internal conversion rate, thereby stabilizing the NIR-II photodynamic rather than photothermal effect. For exerting a combination therapy to eradicate multidrug-resistant biofilms, PNIR-II is further assembled into nanoparticles (NPs) with a synthetic glutathione-triggered NO donor polymer. Under 1064 nm laser radiation, NPs precisely release ROS and NO that triggered by over-expressed GSH in the biofilm microenvironment, thereby forming more bactericidal reactive nitrogen species (RNS) in vitro and in vivo in the mice model that orderly destroy biofilm of multidrug-resistant Staphylococcus aureus cultures from clinical patients. It thus provides a new outlook for destroy the biofilm of deep tissues.