祝贺康晓旭和杨玄坤的文章在Applied Materials & Interfaces接受发表！

康晓旭和杨玄坤在Applied Materials & Interfaces发表题为“GSH/pH Cascade-Responsive Nanoparticles Eliminate Methicillin-Resistant Staphylococcus aureus Biofilm via Synergistic Photo-Chemo Therapy”的文章。本文提出了具有光疗和化疗协同作用的级联响应纳米颗粒（NPs）用于靶向消除生物膜。NP 是通过将 IR780 封装在聚碳酸酯基聚合物中制成的，该聚合物在主链中含有二硫键，并在侧链中连接万古霉素 （Van） 侧链（表示为 SP-Van@IR780 NP）的希夫碱键。SP–Van@IR780 NPs通过Van侧坠的介导在体外和体内特异性靶向细菌生物膜。随后，SP-Van@IR780 NPs被分解成小尺寸，并在GSH存在下由于二硫键的裂解而实现深层生物膜渗透。此后，Van 与 NP 分离，因为当 NP 渗透到生物膜内部时，Schiff 碱键在低 pH 值下SP@IR780断裂。释放的Van和IR780表现出化疗和光疗的强大协同作用，在体外和体内都强烈地消除了生物膜。这些生物相容性SP-Van@IR780 NPs为细菌生物膜感染的治疗提供了新的前景。

Abstract: Bacterial biofilm infection threatens public health, and efficient treatment strategies are urgently required. Phototherapy is a potential candidate, but it is limited because of the off-targeting property, vulnerable activity, and normal tissue damage. Herein, cascade-responsive nanoparticles (NPs) with a synergistic effect of phototherapy and chemotherapy are proposed for targeted elimination of biofilms. The NPs are fabricated by encapsulating IR780 in a polycarbonate-based polymer that contains disulfide bonds in the main chain and a Schiff-base bond connecting vancomycin (Van) pendants in the side chain (denoted as SP–Van@IR780 NPs). SP–Van@IR780 NPs specifically target bacterial biofilms in vitro and in vivo by the mediation of Van pendants. Subsequently, SP–Van@IR780 NPs are decomposed into small size and achieve deep biofilm penetration due to the cleavage of disulfide bonds in the presence of GSH. Thereafter, Van is then detached from the NPs because the Schiff base bonds are broken at low pH when SP@IR780 NPs penetrate into the interior of biofilm. The released Van and IR780 exhibit a robust synergistic effect of chemotherapy and phototherapy, strongly eliminate the biofilm both in vitro and in vivo. Therefore, these biocompatible SP–Van@IR780 NPs provide a new outlook for the therapy of bacterial biofilm infection.