谢文升 副教授

办公地址：北京化工大学朝阳校区科技大厦301-3

联系邮箱：xws@buct.edu.cn

教育背景：

2020/09-2023/06，清华大学，化学系，博士，导师：危岩 （化学生物学）
2016/09-2018/06，清华大学，马克思主义学院，硕士，导师：朱安东 （政治经济学）

2017/03-2017/10，University of New South Wales （UNSW），短期交流，导师：Sophia Gu（肿瘤诊断）
2015/09-2018/06，清华大学，材料学院，硕士，导师：赵凌云 （生物材料）

2013/09-2015/06，清华大学，计算机系，学士 （计算机辅修）
2011/09-2015/06，清华大学，材料学院，学士 （材料科学与工程）

工作经历：

2023/07-至今，北京化工大学，生命科学与技术学院，副教授

2019/02-2020/08，碧桂园集团广东博智林机器人有限公司，高级经理

2018/07-2019/01，碧桂园控股集团，超级碧业生


主要研究领域：
已期刊发表SCI论文50余篇，H-index为21，申请授权发明专利4项，主要研究领域如下：

（1）可降解/全降解功能型纳米材料在肿瘤热疗中的应用研究；

ACS Nano 2024, 18(9), 6975–6989; Chem. Eng. J. 2022, 446, 137310； Adv. Sci. 2022, 9 (4), 2104101； Chem. Eng. J. 2022, 438, 135372； Chem. Eng. J. 2023, 451, 138617； ACS Appl. Bio Mater. 2020, 3 (9), 5845–5855.

（2）基于生物催化的新型纳米酶在肿瘤动力学治疗中的应用研究；

Prog. in Mater. Sci.2023, 138, 101145; Adv Funct Mater 2022, 32 (12), 2107518； Nano Res. 2022, 15 (3), 2244–2253; Materials Today Bio 2022, 100411; Bioactive Materials 2021, 6 (3), 602–612.

（3）新型仿生纳米药物递送系统在肿瘤免疫抑制微环境调控中的应用研究；

J. Mater. Chem. B, 2024, 12, 1194-1207; ACS Appl. Mater. Interfaces 2022, 14 (4), 4995–5008； Nanoscale 2021, 13 (34), 14525–14537； Adv. Healthcare Mater. 2019, 8 (14), 1900203； J. Biomedical Nanotech. 2018, 14, 362–370.

（4）物质的手性界面与细胞识别行为研究;

ACS nano 2024, 18(11), 8017–8028; ACS Appl. Mater. Interfaces, 2024, 16(3), 3202-3214; 

代表性著作：
2024                                 
（1） Guo, Z.; Gao, X.; Lu, J.; Li, Y.; Jin, Z.; Fahad, A.; Pambe, N. U.; Ejima, H.; Sun, X.; Wang, X.; Xie, W.*; Zhang, G.*; Zhao, L.* Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment. ACS Nano 2024, 18 (9), 6975–6989. https://doi.org/10.1021/acsnano.3c10173.
（2） Feng, W#; Chittò, M.#; Xie, W.#; Ren, Q.; Liu, F.; Kang, X.; Zhao, D.; Li, G.; Moriarty, T. F.; Wang, X. Poly(d-Amino Acid) Nanoparticles Target Staphylococcal Growth and Biofilm Disassembly by Interfering with Peptidoglycan Synthesis. ACS Nano 2024, 18 (11), 8017–8028. https://doi.org/10.1021/acsnano.3c10983.
（3） Kang, X.; Yang, X.; Bu, F.; Feng, W.; Liu, F.; Xie, W.; Li, G.; Wang, X. GSH/pH Cascade-Responsive Nanoparticles Eliminate Methicillin-Resistant Staphylococcus Aureus Biofilm via Synergistic Photo-Chemo Therapy. ACS Appl. Mater. Interfaces 2024, 16 (3), 3202–3214. https://doi.org/10.1021/acsami.3c17198.
（4） Liu, Z.; Ma, Y.; Ye, J.; Li, G.; Kang, X.; Xie, W.*; Wang, X.* Drug Delivery System for Enhanced Tumour Treatment by Eliminating Intra-Tumoral Bacteria. J. Mater. Chem. B 2024, 12, 1194–1207. https://doi.org/10.1039/d3tb02362a.

2023                                     
（5） Xie, W.; Guo, Z.; Zhao, L.; Wei, Y. The Copper Age in Cancer Treatment: From Copper Metabolism to Cuproptosis. Prog. Mater. Sci. 2023, 138, 101145. https://doi.org/10.1016/j.pmatsci.2023.101145.
（6） Huang, H.; Xie, W.; Hu, D.; He, X.; Li, R.; Zhang, X.; Wei, Y. Type I Photodynamic Therapy with a Self-Degradable Conjugated Polyelectrolyte in Combination with CpG Adjuvant for Cancer Immunotherapy. Chem Eng J 2023, 451, 138617. https://doi.org/10.1016/j.cej.2022.138617.
（7） Guo, Z.#; Xie, W.#; Gao, X.; Lu, J.; Ye, J.; Li, Y.; Fahad, A.; Zhang, G.; Zhao, L. Nanoheterostructure by Liquid Metal Sandwich-Based Interfacial Galvanic Replacement for Cancer Targeted Theranostics. Small 2023, 19 (22), 2300751. https://doi.org/10.1002/smll.202300751.
（8） Guo, Z.; Gao, X.; Lu, J.; Xu, W.; Ye, J.; Li, Y.; Xie, W.*; Zhao, L.* Recent Advances for Liquid Metals: Synthesis, Modification and Bio-Applications. J Mater Sci Technol 2023, 143, 153–168. https://doi.org/10.1016/j.jmst.2022.08.053.

2022                                         
（9） Xie, W.; Zhang, G.; Guo, Z.; Huang, H.; Ye, J.; Gao, X.; Yue, K.; Wei, Y.; Zhao, L. Shape-Controllable and Kinetically Miscible Copper–Palladium Bimetallic Nanozymes with Enhanced Fenton-like Performance for Biocatalysis. Materials Today Bio 2022, 16, 100411. https://doi.org/10.1016/j.mtbio.2022.100411.
（10） Huang, H.; Xie, W.; Wan, Q.; Mao, L.; Hu, D.; Sun, H.; Zhang, X.; Wei, Y. A Self‐degradable Conjugated Polymer for Photodynamic Therapy with Reliable Postoperative Safety. Adv Sci 2022, 9 (4), 2104101. https://doi.org/10.1002/advs.202104101.
（11） Xie, W.; Ye, J.; Guo, Z.; Lu, J.; Xu, W.; Gao, X.; Huang, H.; Hu, R.; Mao, L.; Wei, Y.; Zhao, L. TME-Responded Full-Biodegradable Nanocatalyst for Mitochondrial Calcium Overload-Induced Hydroxyl Radical Bursting Cancer Treatment. Chem. Eng. J. 2022, 438, 135372. https://doi.org/10.1016/j.cej.2022.135372.
（12） Guo, Z.#; Xie, W.#; Zhang, Q.; Lu, J.; Ye, J.; Gao, X.; Xu, W.; Fahad, A.; Xie, Y.; Wei, Y.; Wu, H.; Boyer, C.; Zhao, L.; Gu, Z. Photoactivation-Triggered in Situ Self-Supplied H2O2 for Boosting Chemodynamic Therapy via Layered Double Hydroxide-Mediated Catalytic Cascade Reaction. Chem. Eng. J. 2022, 446, 137310. https://doi.org/10.1016/j.cej.2022.137310.
（13） Xie, W.; Ye, J.; Guo, Z.; Lu, J.; Gao, X.; Wei, Y.; Zhao, L. Ultrafast Fabrication of Iron/Manganese Co-Doped Bismuth Trimetallic Nanoparticles: A Thermally Aided Chemodynamic/Radio-Nanoplatform for Low-Dose Radioresistance. ACS Appl Mater Interfaces 2022, 14 (19), 21931–21944. https://doi.org/10.1021/acsami.2c02484.
（14） Xie, W.; Lu, J.; Guo, Z.; Guo, X.; Chi, Y.; Ye, J.; Zhang, J.; Xu, W.; Zhao, L.; Wei, Y. Necroptosis-Elicited Host Immunity: GOx-Loaded MoS2 Nanocatalysts for Self-Amplified Chemodynamic Immunotherapy. Nano Res 2022, 15 (3), 2244–2253. https://doi.org/10.1007/s12274-021-3763-7.

2021                                    
（15） Xie, W.; Zhang, G.; Guo, Z.; Lu, J.; Ye, J.; Xu, W.; Gao, X.; Yue, K.; Wei, Y.; Zhao, L. Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/Chemodynamic Nanotherapy. Adv. Funct. Mater. 2021, 32 (12), 2107518. https://doi.org/10.1002/adfm.202107518.
（16） Xie, W.; Zhao, L.; Wei, Y.; Yuan, J. Advances in Enzyme-Catalysis-Mediated RAFT Polymerization. Cell Rep Physical Sci 2021, 2 (7), 100487. https://doi.org/10.1016/j.xcrp.2021.100487.
（17） Xie, W.; Guo, Z.; Zhao, L.; Wei, Y. Metal-Phenolic Networks: Facile Assembled Complexes for Cancer Theranostics. Theranostics 2021, 11 (13), 6407–6426. https://doi.org/10.7150/thno.58711.
（18） Guo, Z.; Lu, J.; Wang, D.; Xie, W.; Chi, Y.; Xu, J.; Takuya, N.; Zhang, J.; Xu, W.; Gao, F.; Wu, H.; Zhao, L. Galvanic Replacement Reaction for in Situ Fabrication of Litchi-Shaped Heterogeneous Liquid Metal-Au Nano-Composite for Radio-Photothermal Cancer Therapy. Bioact Mater 2021, 6 (3), 602–612. https://doi.org/10.1016/j.bioactmat.2020.08.033.
（19） Guo, Z.; Xie, W.; Lu, J.; Guo, X.; Xu, J.; Xu, W.; Chi, Y.; Takuya, N.; Wu, H.; Zhao, L. Tannic Acid-Based Metal Phenolic Networks for Bio-Applications: A Review. J Mater Chem B 2021, 9 (20), 4098–4110. https://doi.org/10.1039/D1TB00383F.

2020以前                                  
（20） Xie, W.; Guo, Z.; Gao, Q.; Wang, D.; Liang, K.; Gu, Z.; Zhao, L. Y. Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Appl Bio Mater 2020, 3 (9), 5845–5855. https://doi.org/10.1021/acsabm.0c00564.
（21） Xie, W.; Guo, Z.; Cao, Z.; Gao, Q.; Wang, D.; Boyer, C.; Kavallaris, M.; Sun, X.; Wang, X.; Zhao, L.; Gu, Z. Manganese-Based Magnetic Layered Double Hydroxide Nanoparticle: A pH-Sensitive and Concurrently Enhanced T1/T2-Weighted Dual-Mode Magnetic Resonance Imaging Contrast Agent. ACS Biomater Sci Eng 2019, 5 (5), 2555–2562. https://doi.org/10.1021/acsbiomaterials.8b01618.
（22） Wang, D.; Xie, W.; Gao, Q.; Yan, H.; Zhang, J.; Lu, J.; Liaw, B.; Guo, Z.; Gao, F.; Yin, L.; Zhang, G.; Zhao, L. Non‐magnetic Injectable Implant for Magnetic Field‐driven Thermochemotherapy and Dual Stimuli‐responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics. Small 2019, 15 (16), 1900511. https://doi.org/10.1002/smll.201900511.
（23） Gao, F.; Zhang, T.; Liu, X.; Ghosal, A.; Wang, D.; Xie, W.; Li, Y.; Wang, X.; Tao, L.; Yu, J.; Wei, Y.; Fan, H. M.; Zhao, L. Nonmagnetic Hypertonic Saline-Based Implant for Breast Cancer Postsurgical Recurrence Prevention by Magnetic Field/pH-Driven Thermochemotherapy. ACS Appl. Mater. Interfaces 2019, 11 (11), 10597–10607. https://doi.org/10.1021/acsami.9b02013.
（24） Xie, W.; Guo, Z.; Gao, F.; Gao, Q.; Wang, D.; Liaw, B.; Cai, Q.; Sun, X.; Wang, X.; Zhao, L. Shape-, Size- and Structure-Controlled Synthesis and Biocompatibility of Iron Oxide Nanoparticles for Magnetic Theranostics. Theranostics 2018, 8 (12), 3284–3307. https://doi.org/10.7150/thno.25220.
（25） Xie, W.; Gao, Q.; Wang, D.; Guo, Z.; Gao, F.; Wang, X.; Cai, Q.; Feng, S.; Fan, H.; Sun, X.; Zhao, L. Doxorubicin-Loaded Fe3O4@MoS2-PEG-2DG Nanocubes as a Theranostic Platform for Magnetic Resonance Imaging-Guided Chemo-Photothermal Therapy of Breast Cancer. Nano Res. 2018, 11 (5), 2470–2487. https://doi.org/10.1007/s12274-017-1871-1.

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教师寄语:

天行健·君子以自强不息，不要忘记当初带着梦想出发时的自己！

招生要求：

对科研：岁月漫长心怀热爱；对未来：星辰大海携手共赴